Blocking is a technique in every installment of the Punch-Out!! series. It can be used to defend against weak punches at the cost of one heart. In Punch-Out!! featuring Mr. Dream, it is performed by pressing down on the Control Pad. In Punch-Out!!, it can be performed one of two ways depending on the control scheme used by the player. When playing with the Wii Remote and Nunchuk, pressing up on the Control Stick activates the maneuver, while when playing with only the Wii Remote in both hands, blocking is done by pressing up on the Control Pad. By blocking, it is possible to actually cancel certain attacks, such as Aran Ryan's headbutt. In Punch-Out!!, the only opponents that have unblockable jabs are TD Disco Kid (but only from the Disco Flurry), and Contender/TD Bald Bull.
In Super_Punch-Out!!_(SNES) however, the player can defend both stomach and face, By not having any directional input, Mac will be by default blocking gut punches, but if the player hold the Up button, Mac will instead cover his face from punches, in the aforementioned game, Uppercuts cannot be blocked and certain Non-Uppercut attacks like Gabby Jay's Taunt Punch, Mr. Sandman's third punch on his Jab Combo, Heike Kagero's Hair Flick and Super Macho Man's Clothesline are also immune to blocking.