Punch-Out!! can refer to:
- Punch-Out!! series, a boxing franchise inspired by the 1984 arcade game of the same name.
- Punch-Out!!, an arcade game developed by Nintendo and released in 1984.
- Punch-Out!!, one of three games released as part of Nintendo's Micro vs. System handheld series, originally released in 1984 as Boxing.
- Punch-Out!! featuring Mr. Dream, the first console title in the series, originally released under the name Punch-Out!!.
- Punch-Out!!, the latest installment of the series, developed by Next Level Games and released for the Wii in May 2009.
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